Cat: HF-1003
Cat: HF-1003
IL3, Human, HEK293 Cells,Tag Free: Product Information
Human IL3; IL3; IL-3; recombinant IL3; interleukin-3; Mast cell growth factor
AAC08706
Human embryonic kidney cell, HEK293-derived human IL3 protein
Ala20-Phe152
15.1 kDa
Solution protein
Dissolved in sterile PBS buffer.
This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage. 12 months from date of receipt, -20 to -70 °C as supplied.
Shipping with dry ice.
> 95%, determined by SDS-PAGE.
<0.010 EU per 1 ug of the protein by the LAL method.
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The EC50 for this effect is 0.01-0.08 ng/mL.
IL3, Human, HEK293 Cells,Tag Free:SDS-PAGE & Bioactivity
Recombinant human IL3 (Catalog # HF-1003) stimulates cell proliferation of the TF-1 human erythroleukemic cells.
Size-exclusion chromatography of recombinant human IL3 protein (280 nm absorbance)
4 ug/lane of recombinant human IL3 was resolved with SDS -PAGE under non-reducing (Lane 1) and reducing (Lane 2) conditions and visualized by Coomassie Blue staining.
IL3, Human, HEK293 Cells,Tag Free:Synonyms
Human IL3; IL3; IL-3; recombinant IL3; interleukin-3; Mast cell growth factor
IL3, Human, HEK293 Cells,Tag Free:Background
Interleukin-3 (IL-3) is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation, and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
1. Meyer CG, et al. (2011) Hum Mol Genet. 20(6):1173-81.
2. Zambrano A, et al. (2010) Curr Alzheimer Res. 7(7):615-24.
3. Dentelli P, et al. (2011) Oncogene. 30(50):4930-40.
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