Cat: MF-1011
Cat: MF-1011
IL11, Mouse, HEK293 Cells,Tag Free: Product Information
P47873
Human embryonic kidney cell, HEK293-derived mouse IL-11 protein
Gly23-Leu199
19.1 kDa
Solution protein.
Dissolved in sterile PBS buffer. This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage. 12 months from date of receipt, -20 to -70 °C as supplied.
Shipping with dry ice
> 95%, determined by SDS-PAGE
> 95%, determined by SDS-PAGE
<0.010 EU per 1 ug of the protein by the LAL method
Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. The EC50 for this effect is 15-31.2 pg/mL.
IL11, Mouse, HEK293 Cells,Tag Free:SDS-PAGE & Bioactivity
Recombinant mouse IL-11 (Catalog # MF-1011) stimulates cell proliferation of the T11 mouse plasmacytoma cells
4 ug/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining.
IL11, Mouse, HEK293 Cells,Tag Free:Synonyms
IL11; IL-11; IL-11Oprelvekin; interleukin 11; interleukin-11; Oprelvekin
IL11, Mouse, HEK293 Cells,Tag Free:Background
IL-11 (Interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27 and IL-31
(1-4). In humans, IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF) (3). The mouse IL-11 cDNA encodes a 199 amino acid (aa) precursor, which generates a 178 aa, 19 kDa mature unglycosylated protein. Mature mouse IL-11 shares 88%, 97%, and 89% aa
sequence identity with human, rat and canine IL-11, respectively. IL-11 is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts, among other cell types (1). It is found in the plasma mainly during inflammation, such as that associated with viral
infection, cancer, or inflammatory arthritis, and is considered to be primarily anti-inflammatory (1). It stimulates hematopoiesis and thrombopoiesis,
regulates macrophage differentiation, and confers mucosal protection in the intestine (1). It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial
proliferation and apoptosis (1). IL-11 synergizes with several other cytokines to produce these effects, and its effects overlap with those of IL-6 (1).
IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11 R alpha subunit and two molecules of the ubiquitously expressed cell signaling beta subunit, gp130 (5).
1. Putoczki, T. and M. Ernst (2010) J. Leukoc. Biol. 88:1109.
2. Paul, S.R. et al. (1990) Proc. Natl. Acad. Sci. USA 87:7512.
3. Kawashima, I. et al. (1991) FEBS Lett. 283:199.
4. Morris, J.C. et al. (1996) Exp. Hematol. 24:1369.
5. Barton, V.A. et al. (2000) J. Biol. Chem. 275:36197.
6. Curtis, D.J. et al. (1997) Blood 90:4403.
7. Baumann, H. et al. (1996) J. Immunol. 157:284.
8. Karow, J. et al. (1996) Biochem. J. 318:489
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