Cat: MF-2025
Cat: MF-2025
, Mouse, HEK293 Cells,Tag Free: Product Information
A2ARV4
HEK293；Gln26-Arg261
27 KDa
Solution protein
Dissolved in sterile PBS buffer.
This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening
Avoid repeated freeze/thaw cycles.
It is recommended that the protein be aliquoted for optimal storage.
12 months from date of receipt, -20 to -70 °C as supplied.
Shipping with dry ice
>90 %, determined by SDS-PAGE
<1.0 EU per 1 ug of the protein by the LAL method
, Mouse, HEK293 Cells,Tag Free:SDS-PAGE & Bioactivity
5 ug/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining.
, Mouse, HEK293 Cells,Tag Free:Synonyms
Pancreatic Lipase-Related Protein 2; PL-RP2; Galactolipase; PNLIPRP2; PLRP2
, Mouse, HEK293 Cells,Tag Free:Background
mLRP2, also known as megalin or gp330, is the largest member of the low-density lipoprotein receptor family, encoded by the Lrp2 gene (MGI:95794) in mice (UniProt: A2ARV4). This type I transmembrane glycoprotein comprises 4,660 amino acids and is highly expressed on the apical surface of absorptive epithelia, particularly in kidney proximal tubules, as well as in the choroid plexus, inner ear, thyroid, and lung . As a multiligand endocytic receptor, mLRP2 mediates the uptake of more than 75 diverse ligands, including lipoproteins, vitamin-binding proteins, hormones, and enzymes, thereby playing an essential role in maintaining metabolic homeostasis . Recent cryo-electron microscopy studies have revealed that mLRP2 functions as a pH-sensitive homodimer that undergoes large conformational changes to facilitate ligand binding at the cell surface and subsequent ligand release within acidic endosomes . Genetic deficiency of mLRP2 in mice results in holoprosencephaly, neural tube defects, and perinatal lethality due to respiratory failure . In humans, loss-of-function mutations in the LRP2 ortholog cause Donnai-Barrow syndrome, an autosomal recessive disorder characterized by low-molecular-weight proteinuria, sensorineural hearing loss, and agenesis of the corpus callosum . Beyond its established roles in development and physiology, emerging evidence links LRP2 dysfunction to various human diseases, including chronic kidney disease, Alzheimer's disease, and certain epithelial cancers .
1、Christensen, E. I. and Birn, H. (2002) Nat. Rev. Mol. Cell Biol. 3:256.
2、Beenken, A. et al. (2023) Cell 186:821.
3、Willnow, T. E. et al. (1996) Proc. Natl. Acad. Sci. USA 93:8460.
4、Kantarci, S. et al. (2007) Nat. Genet. 39:957.
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