Cat: HF-2010
Cat: HF-2010
OSM, Human, HEK293 Cells,Tag Free: Product Information
P13725
Human embryonic kidney cell, HEK293-derived human Oncostatin M/OSM proteinAla26-Arg221
25.8 kDa
Solution protein.
Dissolved in sterile PBS buffer. This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Avoid repeated freeze-thaw cycles. It is recommended that the protein be aliquoted for optimal storage. 12 months from date of receipt, -20 to -70 °C as supplied.
Shipping with dry ice
> 95%, determined by SDS-PAGE
<0.010 EU per 1 ug of the protein by the LAL method
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The EC50 for this effect is 5-30 pg/mL.
OSM, Human, HEK293 Cells,Tag Free:SDS-PAGE & Bioactivity
Recombinant human Oncostatin M/OSM (Catalog # HF-2010) stimulates cell proliferation of the TF-1 human erythroleukemic cells.
4 ug/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining.
OSM, Human, HEK293 Cells,Tag Free:Synonyms
MGC20461; oncostatin M; oncostatin-M; OSM
OSM, Human, HEK293 Cells,Tag Free:Background
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠand typeⅡ both of which share the similarity of containing protein gp130 and takes part in many bio metabolism processes including liver development, hematopoiesis, inflammation, bone formation, and destruction and possibly CNS development. Oncostatin M (OSM) was previously identified by its ability to inhibit the growth of cells from melanoma and other solid
tumors. It also has been reported that OSM, like LIF, IL-6, and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce
their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56
degrees but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-terminal most 31 amino acids produces the fully active 196 residue form.
1. Tanaka M, et al. (2003)Rev Physiol Biochem Pharmacol. 149: 39-52.
2. Auguste P, et al. (1997)J Biol Chem. 272 (25): 15760-4.
3. Zarling JM, et al. (1986)Proc Natl Acad Sci. 83 (24): 9739-43.
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